Dr Kurscheid will present two aspects of his research:
1. How the integration of publicly available datasets was utilised to evaluate the discovery of DNA methylation’s effect on brain cancer progression.
2. The use of multi-dimensional data to study gene-specific effects associated with cell de-differentiation in the process of epithelial-to-mesenchymal transition.
The seminar will furthermore include a brief overview of the wide spectrum of bioinformatics and computational biology research, highlight some historical contributions by computer science, look at current research at JCSMR that may benefit from synergies between life and computer scientists and finally give an outlook on future developments providing rich opportunities for collaborations between computer science, information technology and the life & biomedical sciences.
Dr Sebastian Kurscheid is a research fellow in the Department of Genome Sciences at The John Curtin School of Medical Research. Following his training as a UNIX system programmer and undergraduate degree in molecular biology and biomedical science, Dr Kurscheid was awarded a PhD in Molecular Biology & Bioinformatics from Murdoch University, WA. Subsequently he spent two years as a postdoctoral associate at Yale University, followed by three years as a research assistant in the department for neurosurgery at the University Hospital Lausanne, Switzerland before joining Prof David Tremethick’s lab studying chromatin organisation and its effect on the regulation of transcription. His main research interest is the integrated analysis of genome organisation, epigenetic modifications and associated transcriptional changes in disease and cellular development.